Everyone and everything can inspire..

A small Ant or a Dog, a Spider or an Elephant can inspire us........

We human control the entire planet but still, we failed to dominate our 5 senses.At different situations, we tend to take some wrong steps which compel us to repent for the same mistake throughout our life.

Look at Spider, at situations easy or odd, it maintains patience and as a result, succeeds. But we loose our patience. e.g My life: I myself was at the same juncture of my life. I am a workaholic but unfortunately for nearly 5 months have nothing to work with as I am fighting at all my chances and facing failure. At the mid, I lost my patience started spending time watching movies and so on.......
Thus instead of preparing for the next fight, I surrender, that is where I lost my patience.

Dog can teach the big words like: Faith, Trust, Love and honesty. They can inspire us..

Flowers spread fragrance, Cow teach "Joy of giving", Ant teach Strength, Discipline and hope.

Similarly Iron rod is an example of Strength, Rubber band- Patience and ability to be stable at odd phases.

Its is our ability to observe things which help us to learn from them. It is not the big things which can always teach lessons

Understanding natural mechanism:Maybe a solution to lower HIV viral count.

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Immune system react to every type of infection, it can be Bacterial,Fungal,Mycobaterial or viral.Immune system is a very organized body defensive force which involve receptor binding, Protein/antigen makeover for presentation, ligand binding, followed by signalling and growth of specific cells which work on the antigen.

Immune system is a very big and sensitive system which cannot be cheated easily. The steps of immune system are well defined, harmless to body with regard to low loss of body energy and no involvement of foreign protein or cells other than antigen.

Similarly immune system too has very specific and well defined steps to take during HIV viral invasion. But gradually our immune system weakens due to steep rise in the viral count and resulting in lowering of CD4+ count. But This do not conclude that the system has no answer against the viral growth.

The scientific world has been working on immunological as well as molecular biological aspect of controling HIV viral count eg:Developing plecebo for cytokines or by conducting mutations on the genes responsible for viral entry etc.

These several tests are showing positive result in lab but unable to bring any change in the human body. Government is spending billions on research arena but still answer for the problem is very tricky. This trial to aim at the bulls eye under darkness is causing a conflict of opinion between scientists and Doctors.

It is a high time for a collaboration between Scientists and Doctors. Similarly a thorough study on the activities of immune system on viral invasion should be done. In an International conference on HIV infection in Mumbai it was observed that every scientist and every Phd student was focused on either CD4+ count or molecular biotechnological approach.

Dr.Ghorpade was one of the individual who focused on the game immune system is playing with the concentration of CD8+ cells. He has observed variation in CD8+ count in the HIV patients, which raised questions in his mind on the reason behind this act of immune system.

Like wise Dr Jerome Groopman et al from England 1987 worked with 14 patients and conducted two types of experiment

1. He administered cytokine GM-CSF intravenously and found temporary rise in the WBC count but upon stopping of GM-CSF administration the WBC count fell down.

2. He administered cytokine GM-CSF subcutaneously and found rise in WBC count but upon stopping of GM-CSF administration the level of WBC did not fell. So this gave us some information in the year 1987.

Other example like: Liz Highleyman believed and found that Interleukin-7 again a cytokine administration has experienced significatly greater gains in CD4 and CD8 T-cells.

Now the question lies why these results are showing that addressing different steps of Immune activity and finding out solution from them is showing positive results? Why the counts are increasing?

Those were few of the sparks. There are several more steps take place upon HIV viral infection which need to be studied thoroughly. These entire process is natural phenomenon and answer can might be hidden in natural system.

May be instead of finding ways to lower viral particles or viral cell interaction through molecular biology techniques, why not focus on improving the WBC count or provide stability to the immune system and then allowing the immune system to take necessary action to lower the viral count.

Molecular biological ways, gene therapy are no doubt are revolutionary steps being taken in the arena of research. These methodologies too are giving answers invitro but their response invivo in Human being are feable at times. The consistency of positive response from human model is feable. This response in other words informing us about unacceptance of the above procedures by human body. Then why not understand what is the requsition of our human body system which can atleast lower the viral count.

If we focus on the broader part of the Immune mechanism and narrow ourselves down later might can help us to focus on the minutest steps and variations immune system takes and makes simultaneously to address the problems raised by invading microbes.

As the development of virus and immune system is natural and such for other endemic and epidemic disease(which are extinct now), nature itself has answers for these riddles. But development of defence against these diseases might take time but eventually it will happen, as it happened for the animals which eventually gained immunity or unresponsiveness against these diseases. Eg: Chimpanze against HIV subtypes and Pig against the Japanese Encephalitis virus.